Race/Ethnic Based Genetic Variations in Human Genes: Defining the Genetic Evidence for Disparity of Prostate Cancer Risk and Mortality Between Different Populations
Abstract
Prostate cancer incidence and mortality rates are significantly higher for African-American men than for men of other ethnic groups. The purpose of this study is to determine whether differences in certain human genes can explain why black males are more adversely affected by prostate cancer than white males. The study will evaluate variations in androgen receptor gene, the vitamin D receptor gene, and the APOJ/clusterin gene by amplifying specific DNA segments from certain genes utilizing a commonly used technique called the Polymerase Chain Reaction (PCR). By conducting statistical analyses, associations between genetic markers in these genes and prostate cancer can be evaluated. Further assessments will be made to determine whether the higher risk of prostate cancer among black Americans can be explained by these genetic markers, and whether the same genetic risks exists in other black populations. The scope of this research includes an assessment the a priori hypothesis that the racial disparities in prostate cancer risk and mortality are due to genetic environmental interactions. With this research award the applicant has established the necessary contacts to recruit in the target populations. A personal history survey has been developed, an IRB proposal, and an award proposal has been submitted to initiate experimentation.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 1999
- Accession Number
- ADA380279
Entities
People
- John Franklin
Organizations
- Columbia University