Tumor-Specific Regulation of C-Cam Cell Adhesion Molecule in Prostate Carcinogenesis
Abstract
C-CAM is a tumor suppressor that is lost early in the progression of prostate cancer. The mechanism of C-CAM down-regulation in tumorigenesis is not clear. We propose to unravel the mechanism that down-regulates C-CAM gene expression in prostate carcinogenesis. Identification of early genetic changes in tumorigenesis might yield targets for early prevention and detection. We have identified transcriptional factors, including AP-2 and androgen receptor, that are involved in the regulation of C-CAM gene expression. In addition, we have developed an in vivo functional screening method to identify new transcriptional factors that regulate C-CAM gene expression during prostate carcinogenesis. Results from this study will allow us to design new therapy strategies to alter tumor progression or to implement early detection and prevention strategies.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 1999
- Accession Number
- ADA380313
Entities
People
- Sue-hwa Lin
Organizations
- The University of Texas MD Anderson Cancer Center