Acute Oral Toxicity Evaluation of 2,6-Dibutyl-4-Nitrophenol in Male Sprague-Dawley Rats
Abstract
This study investigated the acute oral toxicity of 2,6-di-t-butyl-4-nitrophenol (DBNP) in male Sprague-Dawley rats. DBNP is formed in U.S. submarines when lube oil containing the antioxidant additive 2,6-di-t-butylphenol (DBP) is nitrated after passing through an electrostatic precipitator. DBNP has triggered human health concerns due to its adherence to painted surfaces causing a noticeable yellowing. Male Sprague-Dawley rats were dosed with DBNP in corn oil. Survivors at each dose level were 5/5 at 62.5 mg/kg, 4/5 at 78 mg/kg, 2/5 at 98 mg/kg, and 015 at 250 mg/kg. The LD50 of DBNP in corn oil is 93 mg/kg. The No Observable Effect Level for DBNP is less than 62.5 mg/kg. Hyperthermia and severe rigor were found in treated animals.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1999
- Accession Number
- ADA380383
Entities
People
- G. B. Briggs
- K. L. Macmahon
- K. R. Still
- W. H. Baker
- W. K. Alexander