Human Monoclonal Antibodies for Neutralization of Botulinum Neurotoxin
Abstract
The overall goal of this proposal is to produce neutralizing human monoclonal antibodies against Botulinum neurotoxins for immunoprophylaxis and immunotherapy. Antibodies will be generated using a novel approach, phage display, which overcomes the limitations of conventional hybridoma technology. The proposal represents a continuation of work begun under DAMD17-94-C-4034 titled "Production of Human Antibodies which Neutralize Botulinum Neurotoxin Type A". In the sections below, we first describe the problem, the limitations of currently available reagents, the novel approach we have used for this work (phage display), results obtained to date under DAMD17-94-C-4034, and specific aims and experimental design for the current preproposal.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 1999
- Accession Number
- ADA380394
Entities
People
- James D. Marks
Organizations
- University of California, San Francisco