Role of Nuclear Receptor Coactivators AIB-1 and SRC-1, in the Development of Breast Cancer
Abstract
Steroid hormones are involved in the development and growth of the breast cancer. Drugs which inhibit estrogen action are commonly used to inhibit breast cancer growth. Unfortunately, most advanced breast cancer become resistant to estrogen treatment. Recently, many steroid receptor coactivators have been discovered and found to potentiate the transcriptional activity of steroid receptors and enhance the expression of hormone response genes. SRC-1 family of coactivator, AIB1 is found amplified and/or over-expressed in breast cancer specimens. To evaluate the potential roles of SRC-1 family of coactivators in mammary tumorigenesis in vivo, we proposed to generated transgenic mice over-expression of AIB1 (SRC-3) in mammary glands. To target the expression of AIB1 1 in mammary gland, we placed the AIB1 1 transgene under the control of the MMTV-LTR promoter. Two lines of transgenic mice expressing AIB1 1 have been generated. Studies on these transgenic mice will help understanding the development and progression of breast cancer and provide molecular basis for design novel strategies to curb and ultimately cure breast cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2000
- Accession Number
- ADA380919
Entities
People
- Sophia Tsai
Organizations
- Baylor College of Medicine