The Brcal Tumor - Suppressor Gene in a Mouse Model of Breast Cancer
Abstract
BRCAl is a tumor-suppressor locus on chromosome 17q2l. Familial inheritance of a defective copy places a lifetime risk of breast cancer at 80%. Most of these tumors arise before the age of 50. In addition, there is an elevated risk of ovarian and testicular tumors. The mechanism of transformation is not known. In an effort to better understand the actions of this gene, I have cloned the mouse Brca1 gene. The present proposal aims to characterize the effect of over-expression and deletion of Brcal in mice, and by understanding the nature of the interactions between Brcal and other oncogenes. The completion of these aims will provide: (1) a mouse model of Brcal deficiency, (2) an enhanced understanding of Brca1 function in the regulation of mammary epithelial cell growth and differentiation, and (3) reveal important interactions between Brcal and other potent transforming agents in the breast, in particular with c-m9yc, and loss of p53.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1999
- Accession Number
- ADA381044
Entities
People
- Timothy F. Lane
Organizations
- University of California, Los Angeles