WNT-1 Signaling in Mammary Carcinogenesis
Abstract
WNT genes encode a large family of secreted signaling molecules essential for development and oncogenesis. wnt-1, the founding member of the wnt gene family, was initially identified as an oncogene which, upon ectopic expression induced by viral insertion, causes mammary tumorigenesis in mice, providing a potential model for studying human breast cancer. However, the Wnt- 1 receptor, an essential component mediating Wnt- 1 function, has not been identified, and the molecular and biochemical nature of the Wnt signaling pathway is not fully understood. In this proposal for the Career Development Award, we propose experiments combining molecular techniques and the axis duplication assay in the Xenopus embryo to answer the following two critical questions: 1) What is the receptor mediating Wnt- 1 oncogenic function? 2) How does the Dishevelled protein, which is an essential Wnt signaling component, transduce Wnt-1 signal? These experiments should provide a better understanding of the molecular nature of Wnt-1 signaling in mammary malignancy.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 1999
- Accession Number
- ADA381046
Entities
People
- Xi He