Critical Body Residue (CBR) Approach for Interpreting the Consequences of Bioaccumulation of Neutral Organic Contaminants

Abstract

This technical note describes a procedure for interpreting tissue residues of neutral organic chemicals generated in 28-day dredged material bioaccumulation bioassays. This interpretive guidance uses a critical body residue (CER) of neutral organic chemicals reported for the fathead minnow, Pimephales promelas. The CBR is based on a very large U.S. Environmental Protection Agency (EPA) acute toxicity database and well accepted quantitative structure activity relationships (QSARs). Guidance in this technical note is not appropriate when xenobiotic metabolism of neutral organic contaminants is likely.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 1992
Accession Number
ADA381061

Entities

People

  • Alfreda Gibson
  • Thomas M. Dillon

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Animals
  • Aquatic Organisms
  • Aromatic Polycyclic Hydrocarbons
  • Chemical Synthesis
  • Chemistry
  • Databases
  • Ecology
  • Ecotoxicology
  • Environmental Protection
  • Eutrophication
  • Fish
  • Habitats
  • Molecular Weight
  • Organic Chemistry
  • Toxicity

Fields of Study

  • Environmental science

Readers

  • Agricultural Chemistry/Soil Science
  • Aquatic Ecology
  • Coastal and Marine Engineering/Sediment Transport/Hydraulic Engineering