Regulation of TGF-Beta Signal Transduction Pathways in Breast Cancer

Abstract

The goal of my studies under the BCRP fellowship is to understand the role of the Smad proteinS and the TGF-beta signal transduction pathways in breast cancer cell proliferation, tumor progression, and prognosis. In the past nine months, I have focused on identifying intracellular molecules and transcription factors that might be involved in the TGF-beta signal transduction pathway. Using both genetic and biochemical approaches, I have successfully isolated a few key molecules that are either mediator of the TGF-beta induced transcriptional response or suppressors of the TGF-beta signal pathways. Future studies will be focused on understanding the detail mechanism of how the molecules interplay in mediating TGF-beta signaling and the significance of these interactions in tumor cell proliferation, progression, and prognosis.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 1999
Accession Number
ADA381137

Entities

People

  • Xuedong Liu

Organizations

  • Whitehead Institute

Tags

DTIC Thesaurus Topics

  • Biomedical And Dental Materials
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Genetics
  • Health Services
  • Medical Personnel
  • Peptide Growth Factors
  • Peptides
  • Polymer Chemistry
  • Polymeric Films
  • Proteins
  • Proteomics

Fields of Study

  • Medicine

Readers

  • Breast cancer cell signaling and growth regulation.

Technology Areas

  • Biotechnology