The Role of Steroid Receptor Coactivator-1 in Breast Cancer
Abstract
The steroid hormones estrogen and progesterone and their intracellular receptors have been Implicated in the development and progression of primary epithelial breast cancer. Regulation of gene expression by hormone-bound steroid receptors Is mediated by members of the steroid receptor coactivator (SRC) family. The purpose of this study was to examine the role of SRC-1 in the regulation of gene expression by steroid receptors. In breast cancer SRC-1 was found to exist in a multifactor complex which was stably associated with liganded progesterone receptor, implicating an active SRC-1 complex as a primary target of liganded PR in breast cancer cells. In an effort to further define the role of SRC-1 in breast cancer, we characterized a member of the active SRC-1 complex, SRA (steroid receptor RNA coactivator), which was shown to function as an RNA. Significantly, SRA Is a limiting factor required for efficient transcriptional activation by steroid hormone receptors in breast cancer cells.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1999
- Accession Number
- ADA381169
Entities
People
- Neil J. Mckenna
Organizations
- Baylor College of Medicine