The Assessment of Prostate Cells in Semen Using Flow Cytometry, For the Early Detection and Staging of Prostate Cancer (Prostate)
Abstract
This study involves the detection of pro static epithelial cells in the seminal fluid. Relatively normal cells are identified by Cytokeratin 8/18. Up-regulated, or cancerous cells, are identified by means of PSMA staining. Increased prostate specific membrane antigen is associated with a poor prognosis. Data is being collected to differentiate the seminal fluid values in a ratio between the cytokeratin cells and the PSMA positive cells. At the present time, these clearly distinguish between BPH patients and prostate cancer patients, with prostatitis patients being intermediate. As more and additional patients are followed for repeat studies, and additional patients are seen from our control vasectomy clinic, we will define this test to its ultimate possibilities. The obtaining of fresh samples and the elimination of viable sperm have been two of our key progress notes at this particular time.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1999
- Accession Number
- ADA381183
Entities
People
- Gerald Murphy