Synthesis of Clustered ST-Antigens for the Development of Novel Breast Cancer Vaccines
Abstract
The development of efficient routes for the preparation of complex oligosacoharide or carbohydrate conjugates has been a goal in the Danishefsky group for some time. Synthetic investigations in this area can help to provide a detailed knowledge of the structural and chemical behavior of carbohydrates and their conjugates. Moreover, it has been known for some time now that specific types of glycolipids or glycoproteins, which are chemically detectable in normal cells, are more highly expressed in tumors. It should be noted that abnormally high levels of expression on tumor cells cause an antibody response, consequently rendering the cell- surface glycoconjugate a tumor-associated antigen. The idea of such glycoconjugates as tumor-associated antigens is the basis for using carbohydrates in the development of antitumor vaccines. Since tumor antigens and vaccine constructs are usually inaccessible from natural sources, it falls to the organic chemist to supply necessary quantities of carbohydrates, in the form of both glycolipids and glycopeptides.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2000
- Accession Number
- ADA381188
Entities
People
- Matthew W. Carson
- Samuel J. Danishefsky
Organizations
- Memorial Sloan Kettering Cancer Center