Molecular Diagnosis for Breast Malignancy

Abstract

The overall project goal is to identify and evaluate new prognostic markers that can be used to indicate the metastatic potential of node-negative breast cancer. Cell surface antigens in the invading front; invadopodia, of cancer cells are considered as promising diagnostic indicators of metastatic potential. Five invasion-associated proteins are being examined in this project: seprase, dipeptidyl peptidase IV (DPPIV), membrane type matrix metalloprotease (MT-MMP), fibronectin, and extracellular matrix metalloprotease inducer (EMMPRIN).

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1998
Accession Number
ADA381191

Entities

People

  • Wen-tien Chen

Organizations

  • Georgetown University

Tags

DTIC Thesaurus Topics

  • Blood
  • Breast Cancer
  • Cancer
  • Cell Membrane
  • Cells
  • Chemistry
  • Epidermis
  • Epithelial Cells
  • Health Services
  • Medical Personnel
  • Oncology
  • Tissue Extracts

Readers

  • Molecular Biology and Genetics
  • Molecular and Cellular Biochemistry