Role of HMG-I(Y) in Human Breast Cancer Metastasis

Abstract

HMG-I(Y) proteins are mammalian architectural transcription factors. They have been demonstrated to be necessary for the transcriptional regulation of a number of genes, including the genes associated with tumorigenesis and metastasis. It was proposed in the original grant that over-expression of HMG-I(Y) proteins in breast cancer cells will fundamentally influence the expression of genes that are involved in metastatic invasion, migration, angiogenesis and colonization. In the three years of study, the results support the hypothesis.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1999
Accession Number
ADA381246

Entities

People

  • Ying Li

Organizations

  • Washington State University

Tags

DTIC Thesaurus Topics

  • Biomedical And Dental Materials
  • Breast Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Culture Techniques
  • Genetics
  • Lymphocytes
  • Neoplasms
  • Peptide Growth Factors
  • Peptides
  • Polymeric Films
  • Proteins
  • Stem Cells
  • Tumor Cell Line

Readers

  • Molecular Biology and Genetics
  • Oncology (Cancer Research).
  • Petroleum Engineering