The Use of Exercise to Increase CD4 (+) T Lymphocytes Following Chemotherapy Treatment for Breast Cancer
Abstract
Chemotherapy, frequently given to breast cancer patients, destroys lymphocytes as well as cancer cells. It had been observed that the T to the sub H cell (CD4+ lymphocyte) population in the blood is very slow to recover. We observed that in healthy women a resistance exercise program brought about an increase in blood CD4+ T cells. Therefore the goal of this study was to determine if an appropriately designed exercise program would help in the recovery of CD4+ T cells following chemotherapy/radiation. The major accomplishments during this first reporting period are 1) the establishment of a recruitment system; 2) approval by the General Clinician Research Center; 3) the establishment of the functional (mitogen, cytokine) and phenotypic (differentiation and activation markers) assays; 4) the establishment of an exercise protocol and the training of personal trainers. The first subject, enrolled in February of 1998 has now completed 3 months of exercise training. There are 9 subjects enrolled at this time. The data are not complete for any one patient due to the long course of treatment However, a decrease in lymphocyte function and phenotype following chemotherapy is apparent from the preliminary results.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1999
- Accession Number
- ADA381287
Entities
People
- Andrea M. Mastro
Organizations
- Pennsylvania State University