Breast Cancer Biomarkers Based on Nipple and Fine Needle Aspirates

Abstract

The purpose of this proposal was twofold: 1) to compare the success of experienced vs. inexperienced individuals in collecting nipple aspirate fluid (NAF) and fine needle aspirate (FNA) samples, and 2) to compare biomarker results in these specimens, including cytology, ploidy, cell cycle parameters, p53, proliferation index, epidermal growth factor receptor, and prostate-specific antigen. Each of these biomarkers has been evaluated in FNA and/or NAF samples. Each of the methods of specimen collection have limitations, suggesting that combining the information gained from each modality may tell the physician more about a subject's breast cancer risk. We have just received final approval from our institutional review board (IRB) at Fox Chase Cancer Center. The protocol is currently under review by the JRB at Kansas University Medical Center (KUMC). A trip has already been made to KUMC to learn the FNA procedure. Subject accrual should soon begin.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 1999
Accession Number
ADA381296

Entities

People

  • Edward R. Sauter

Organizations

  • Fox Chase Cancer Center

Tags

DTIC Thesaurus Topics

  • Animals
  • Biological Factors
  • Biological Markers
  • Biomedical Research
  • Body Fluids
  • Breast Cancer
  • Cell Physiological Processes
  • Diseases And Disorders
  • Federal Law
  • Growth Factors
  • Institutional Review Board
  • Laboratory Animals
  • Materials
  • Medical Personnel
  • Neoplasms
  • Physicians
  • Universities

Readers

  • Oncology and Biomarker-Based Cancer Detection.
  • Systems Analysis and Design