C-ERBB-2 Receptor Signaling and Breast Cancer Metastasis
Abstract
Overexpression of the c-erbB2 gene is correlated with poor prognosis and the number of lymph node metastases in breast cancer patients. Our previous work has demonstrated that erbB2 enhances the intrinsic metastatic potential of human breast cancer cells. We hypothesize that the erbB2-encoded receptor tyrosine kinase (RTK) may enhance metastatic potential through the RTK- signaling molecules. The purpose of this study is to test whether the increased c-erbB2 tyrosine kinase activity and tyrosine autophosphorylation on the carboxyl-tenninal tall may be required for the downstream signaling involved in breast cancer metastasis. We have completed the Tasks 1, 2, 3 as stated in the Statement of Work of our proposal. Tasks 4, 5, 6, of the proposal are ongoing. We have published a paper on Cancer Research, which is resulted from this grant support. Currently, we are studying the metastatic potential of FACS sorted wild-type and erbB2 mutant transfectants in vitro and in vivo. Also, we are studying the erbB2 downstream signaling molecules which may contribute to erbB2 enhanced cancer metastasis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 1999
- Accession Number
- ADA381306
Entities
People
- Ming Tan
Organizations
- The University of Texas MD Anderson Cancer Center