NMR with Combined Antiangiogenic and Radiation Therapies - Breast Cancer
Abstract
The original goal of the present study was to determine optimal strategies for combining radiation and antiangiogenic therapies in spontaneous murine tumors and to evaluate the potential of Nuclear Magnetic Resonance (NMR) blood flow, arterial spin tagging, and oxygen measurements, (19)F oximetry, to guide the planning of combined treatment. Antiangiogenic therapy was found to have only minimal effect in the tumor model. In contrast, we have discovered that antivascular therapies have a significant effect on tumor blood flow (Lew et al. Cancer Res. 59: 6033-7, 1999) and when combined with radiation have a profound effect on tumor response (manuscript in preparation, results presented at AACR in San Francisco in 1999, Abstract #1869). The specific aims are modified slightly: Aim 1: To measure the response of spontaneous murine mammary carcinoma to combined radiation and antiangiogenic/antivascular therapies under variations of order and timing of the two modalities. Aim 2: To measure changes in tumor oxygen and blood flow following radiotherapy or antiangiogenic/antivascular therapy. We have completed the tumor response studies using radiation plus drug and we have completed the autoradiography blood flow studies (manuscript in preparation). The NMR blood flow and (19)F oximetry studies are in progress. The project is on schedule.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2000
- Accession Number
- ADA381308
Entities
People
- Stephen Brown
Organizations
- Henry Ford Health