Factors Modulating Estrogen Receptor Activity

Abstract

The overall goal of our laboratory is to elucidate the mechanism of signal transduction and transcriptional regulation by the estrogen receptor (ER), a ligand- regulated transcription factor that plays a critical role in the development, progression and hormone responsiveness of breast cancer cells. Combining genetic, molecular and biochemical approaches, we have identified the Hsp9O-associated co-chaperone, p23, as a key regulator of ER action and have also determined that ER is phosphorylated and regulated by the cyclin A/Cdk2 complex. Understanding of the communication between ER and these regulator factors is fundamental to understanding the mechanism of ER- regulated gene expression and may reveal novel points of intervention to be exploited in the development of new therapies for breast cancer.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1999
Accession Number
ADA381691

Entities

People

  • Michael J. Garabedian

Organizations

  • NYU Langone Health

Tags

DTIC Thesaurus Topics

  • Albumins
  • Biomedical And Dental Materials
  • Breast Cancer
  • Cell Line
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Chromosomes
  • Fungi
  • Genetic Structures
  • Genetics
  • Organic Chemistry
  • Polymer Chemistry
  • Polymeric Films
  • Proteins
  • Transcription Factors

Readers

  • Molecular Biology and Genetics

Technology Areas

  • Biotechnology