Mutations in ATM, Radiation Exposure and Breast Cancer Risk Among Black and White Women
Abstract
In some families, predisposition to breast cancer is inherited as a genetic trait thus far, a few highly penetrant genes responsible for inherited breast cancer have been identified. An important and unresolved question of breast cancer etiology is whether there are other genes which have a more moderate effect on breast cancer risk, possibly involving more women than do other inherited mutations. It has been suggested that mutations in the Ataxia-Telangiectasia gene (ATM) and cellular damage such as radiation exposure could be involved with breast cancer in this manner. In order to address this question, we screened a population-based series of African-American and Caucasian breast cancer patients and controls as well as a series of patients with particular phenotypes for mutations in the ATM gene. This study was designed to detect potential mutations in the ATM gene which confer breast cancer risk.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 1999
- Accession Number
- ADA381762
Entities
People
- Elizabeth Schubert
Organizations
- University of Washington