The Role of Substance P in a Model of Chronic JP-8 Jet Fuel

Abstract

13. ABSTRACT (Maximum 200 words) We have establ%s'hed a good dose-response relationship for JP-8 jet fuel exposure in our mouse model and further elucidated the role(s) of substance P in the lung injury cascade initiated by JP-8 jet fuel exposure. Additionally, we have established good working relationships with Drs. Harris, Witzmann and Siegel and these relationships are becoming productive in producing addtional JP-8 jet fuel-related research. We will establish a mouse viral model in the next three years of support from AFOSR as well as continue our studiesof SP in this model. We will ascertain whether a pre- existing respiratory infection followed by JP-8 jet fuel exposure is synergetic to cause significant lung injury. Additionally, we will examine the lung proteomics of a minimum JP-8 jet fuel dose, 5Omg/m, that we know to cause pathological lung injury in collaboration with Dr. Witzmann.

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Document Details

Document Type
Technical Report
Publication Date
Jun 09, 2000
Accession Number
ADA382194

Entities

People

  • Mark L. Witten

Organizations

  • University of Arizona

Tags

DTIC Thesaurus Topics

  • Air Force
  • Cells
  • Chemistry
  • Culture Techniques
  • Diseases And Disorders
  • Environmental Health
  • Epithelial Cells
  • Fuels
  • Hydrocarbons
  • Infection
  • Jet Engine Fuels
  • Macrophages
  • Medical Personnel
  • Patent Applications
  • Pulmonary Function
  • Scientific Research
  • Wounds And Injuries

Readers

  • Immunology and Pathology
  • Petroleum Engineering
  • Technical Research and Report Writing.

Technology Areas

  • Biotechnology