Contrast Enhanced 3D Color Amplitude Imaging of the Breasts
Abstract
In total, 22 patients with 6 cancers and 16 benign lesions have been enrolled in the Levovist arm of the study. These numbers were less than anticipated, and an initial data analysis indicated that Levovist was not as efficacious as expected. To increase recruitment and improve results the ultrasound contrast agent was changed to Optison. To date 13 patients with 3 cancers and 10 benign lesions have been enrolled in this part of the study. Moreover, 3D parameter extraction algorithms for the LIS 6000A system has been designed and tested, but no data analysis has yet been carried out due to the limited data set available for Optison. The histomorphometry system has been used to analyze vessel distribution and vessel density maps from 10 patients. Contrast enhanced color flow imaging was found to provide some quantitative parameters, which correlated with direct pathologic vascularity assessments such as the iMVD. Specifically, the microvessel area and count for vessels 30 to 39 microns in diameter were most significant. These results indicate that ultrasound imaging with contrast may produce a quantitative measure of the neovascularity within breast tumors. However, the current patient population in the sub-study is very small and further cases are currently being analyzed.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1999
- Accession Number
- ADA382383
Entities
People
- Flemming Forsberg
Organizations
- Thomas Jefferson University