Disaster Relief and Emergency Medical Services Project (DREAMS TM): Clinical and Basic Science Projects
Abstract
DREAMS clinical and basic science projects complement the digital EMS effort by investigating the mechanisms of tissue injury in order to minimize the mortality and mortality of trauma and "natural" injuries such as heart attacks. We have a broad effort aimed at the major problems: oxidation (common to resuscitation/reperfusion injuries of heart, brain, liver and kidney), toxins, apoptosis, inflammation, cell proliferation and angiogenesis. We have made progress in understanding the genes controlling anthrax, and those of the human P450 defense system; we have developed new probes to help interventionalists and surgeons diagnose tissue types and distinguish inflammation and necrosis in real time; a field implantable pump has been developed to boost cardiac output in order to prevent the viscous cycle of low cardiac output causing ischemia; we have increased our understanding of the denitration of NO (the gas that regulated blood pressure, clotting, oxidant defense against microbes, nerve Cell communication, cell proliferation and death); we have learned more about the roles played by PPAR gamma, ICAM1, E-selectin and VCAM1 in inflammation, finally, we have learned new ways to introduce genes into cells and have demonstrated new possibilities in gene therapy while uncovering new problems with a current technique of gene therapy.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 1999
- Accession Number
- ADA382548
Entities
People
- Ward Casscells
Organizations
- University of Texas at Austin