Role of Human DNA Polymerase and Its Accessory Proteins in Breast Cancer
Abstract
Thus far the mechanisms for genetic errors and genomic instability in breast cancer cells have not been fully delineated. Defects in DNA polymerase delta and its accessory proteins could contribute to the molecular etiology of breast cancer. DNA polymerase delta and its accessory proteins are involved in both DNA replication, repair, recombination and transcription. There are linkages between polymerase delta and cell cycle regulation via protein-protein interaction of polymerase processivity factor PCNA with p21, a cyclin dependent kinase inhibitor. We are approaching this study in a multifaceted manner at the protein, message and gene level. It is hoped that the results from these studies will provide a deeper understanding of the linkage between regulation of polymerase delta and its accessory proteins and carcinogenesis in breast cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1998
- Accession Number
- ADA382695
Entities
People
- Marietta Lee
Organizations
- University of Miami