Effect of Inherited Breast Cancer Susceptability on Treatment Outcomes After Conservative Surgery and Radiation Therapy
Abstract
The presence of a mutation in a tumor suppressor gene, such as BRCAl, may have implications for patient management if patients with these mutations can be identified. Specifically, treatments such as breast conserving surgery and radiation therapy may be inappropriate if these patients are likely to be more susceptible to radiation-induced carcinogenesis or if they are more likely to recur locally in the breast because of multicentric disease. We have to date identified 189 eligible patients diagnosed with breast cancer at age 38 or younger and treated at the Joint Center for Radiation Therapy (JCRT) between l987-95 of the 226 whom we expect to eventually contact. Patient accrual is steady and ongoing with 39 patients accrued to date. Lymphocytes from study subjects are being collected, immortalized and stored in liquid nitrogen. At the end of the two year collection period, testing for the presence of a germ-line BRCAl mutation will be performed. Treatment outcome will then be compared between the groups of patients with and without mutations in BRCAl. In addition we have begun identifying our on treatment cohort of patients currently undergoing radiation therapy, and plan to begin enrolling this group early next month.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1999
- Accession Number
- ADA382703
Entities
People
- Asa J. Nixon
Organizations
- Dana–Farber Cancer Institute