Non-Invasive Detection of Axillary Nodes by Contrast Enhanced Magnetic Resonance Imaging

Abstract

Previous studies in murine tumors have shown that the 3 drug combination of PALA + MMPR + 6AN (PMA) PALA (n-phosphonacetyl aspartate), MMPR (6-methylmercaptopurine riboside), 6AN (6- aminonicotinamide); referred to as PMA is an effective radiation (XRT) sensitizer. Using the MCF-7 human mammary tumor, we detected 6-phosphogluconate (6PG), an intermediate in the pentose phosphate pathway, and a reduction in nucleoside triphosphates after treatment with PMA in vivo. In vivo studies indicated that PMA induces a tumor response as evidenced by an increase in tumor growth delay from 10.2 +/-4.6 (control) to 29.3 +/- 6.7 days. Neither PMA nor XRT alone induced tumor shrinkage. PMA yields 5 Gy induced tumor shrinkage and after 33 days the tumors had not attained their pretreatment volume. By day 51, the mice still had not doubled their tumor volume, indicating that PMA is an active regimen in human tumors, and an effective XRT sensitizer. We also investigated the efficacy of combining with paclitaxel with bryostatin.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1999
Accession Number
ADA382736

Entities

People

  • Jason A Koutcher

Organizations

  • Memorial Sloan Kettering Cancer Center

Tags

DTIC Thesaurus Topics

  • Azo Compounds
  • Blood Flow
  • Cell Line
  • Cell Physiological Processes
  • Chemistry
  • Detection
  • Drug Abuse
  • Health Services
  • Magnetic Resonance
  • Magnetic Resonance Imaging
  • Medical Personnel
  • Neoplasms
  • Proteins
  • Resonance
  • Tumor Cell Line
  • X-Ray Computed Tomography

Readers

  • Allergy and Immunology.
  • Oncology (Cancer Research).
  • Parasitology and Pharmacology of Malaria.