Semiannual Report to the Atomic Energy Commission
Abstract
Many patients with acute leukemia exhibit abnormalities of chromosome number or morphology in the affected (leukemic) cells which may be constant in any one patient, but may vary 12 considerably from one patient to another. Although it is presumed that these chromosomal abnormalities are related to the neoplastic behavior of leukemic cells, their precise role in the evolution of the leukemic state remains to be determined. Direct evidence bearing on this issue would accrue from systematic analyses of chromosome constitution beginning with the presumably normal subject, progressing through the pre-leukemic phase, and culminating in the overtly leukemic stage in affected individuals. Such evidence has not been forthcoming because human acute leukemia is still a relatively rare disorder, most cases of which occur sporadically, apparently arising de novo, and usually not recognized until clinically manifest. However, the occurrence of certain hematologic syndromes with a propensity to terminate in acute 4 leukemia, affords an opportunity to assess the importance of chromosomal alterations in the pathogenesis of leukemia. These pre-leukemic or, more precisely, potentially leukemic syndromes, may be classified into the aplastic, myelodysplastic, and myeloproliferative disorders.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1966
- Accession Number
- ADA382744
Entities
People
- Leon O. Jacobson
- Margot Doyle