Evaluation of Antileishmanial Drugs in Animal Models
Abstract
A total of 34 selected compounds, including natural products, some compounds known to be efficacious against other diseases, cholesterol lowering drugs currently in use in human beings, and pro drugs of the pentamidine type were studied in hamsters at various dosage levels, via various routes and treatment schedules for antileishmanial efficacy against Leishmania (leishmania) donovani. One of the same compounds (Baycol) was studied for efficacy against Leishmania (Viannia) panamensis and leishmania ma%or and three other compounds were studied for efficacy against leishmania (V%.) panamensis. Only two of these compounds had any efficacy against visceral leishmaniasis (BN97515 and an analog of Amphotericin B). The activity of the Amphotericin B analog was not as great as Amphotericin B and BN97515 was active but toxic. None were active against cutaneous leishmaniasis. Several topical ointment preparations (containing the same drug but different water concentrations) were highly efficacious in mice against cutaneous lesions caused by leishmania major. When biopsy cultures obtained by WRAIR from human and canine patients with suspected infections with Leishmania were injected into hamsters and/or mice via various routes, the presence of cutaneous leishmaniasis was confirmed in 38 human patients and the presence of visceral leishmaniasis was confirmed in 8 other patients (5 human beings and 3 canines).
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2000
- Accession Number
- ADA382788
Entities
People
- William L. Hanson
Organizations
- University of Georgia Research Foundation