Molecular Epidemiology of Breast Carcinoma In Situ
Abstract
This is a molecular epidemiologic case-control study of breast carcinoma in situ in Los Angeles County designed to address issues related to the cause and progression of breast CIS by determining epidemiologic risk factors, characterizing selected molecular genetic alterations and prospectively assessing disease progression. The specific aims of the research are 1.) to assess epidemiologic risk factors associated with development of breast CIS, 2.) to determine how frequently specific oncogenes or the p53 tumor suppressor gene are altered in breast CIS, 3.) to investigate potential relationships between various epidemiologic risk factors and somatic genetic alterations and 4.) to assess long-term the association of these factors with disease progression. During the four-year grant period we plan to interview approximately 100 black women and 426 white women (including Hispanics) aged 35-64 years who are diagnosed with breast CIS and who are residents of Los Angeles County, are US-born, and English speaking. The study will utilize 490 black and 490 white control subjects selected by random digit dialing in Los Angeles County who will have been interviewed as part of the Women's CARE Study, a multicentered case-control study of invasive breast cancer being conducted concurrently with this proposed study. We will obtain paraffin-embedded tumor tissue from the pathology laboratories where the patients were diagnosed for analysis of alterations in selected oncogene and tumor suppressor gene expression. Epidemiologic risk factors (reproductive history, lack of participation in physical activity/exercise, positive family history, race, high body mass and exposure to hormones) will be compared with oncogene and tumor suppressor gene expression in breast CIS.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1999
- Accession Number
- ADA382806
Entities
People
- Michael Press
Organizations
- University of Southern California