ErbB2 Regulation of C-src Activity in Breast Cancer

Abstract

Transfection of normal mammary epithelial cells with ErbB2 induced tumorigenic transformation and was associated with increased c-src activity. Transformation with other oncogenes did not affect c-src activity. Induction of c-src activity was found to he associated with decreased phosphorylation on Y527 of c-src. This decreased Y527 phosphorylation was associated with increased association of the phosphotyrosine phosphatase SHP2 with ErbB2. Dominant negative SHP2 inhibited association of phosphotyrosine phosphatases with ErbB2 and ErbB2-induced src activity.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2000
Accession Number
ADA382846

Entities

People

  • Lewis Sheffield

Organizations

  • University of Wisconsin–Madison

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Acids
  • Breast Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Culture Media
  • Epithelial Cells
  • Materials
  • Medical Personnel
  • Neoplasms
  • Peptides
  • Phosphorylation
  • Proteins
  • Regulations
  • Transfection

Readers

  • Breast cancer cell signaling and growth regulation.