Identification of Protein Components of Yeast Telomerase

Abstract

Telomere length is tightly regulated in Saccharomycetes. This lengthening is dependent on TLC1, which encodes the RNA component of telomerase but independent of RAD52, which encodes a protein required for most recombination events in mitotic yeast cells. Most cells lacking yeast telomerase die but survivors arise by RAD52 dependent events: the majority of these survivors have tandem duplications of the sub-telomeric Y' element.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1999
Accession Number
ADA382853

Entities

People

  • Shu-chun Teng

Organizations

  • Princeton University

Tags

DTIC Thesaurus Topics

  • Cell Division
  • Cell Line
  • Cells
  • Chemistry
  • Chromosome Structures
  • Cultured Cells
  • Eukaryotes
  • Fungi
  • Gel Electrophoresis
  • Gene Expression
  • Genes
  • Genetic Code
  • Genetics
  • Identification
  • Maintenance
  • Materials
  • Polymerase Chain Reaction

Fields of Study

  • Biology

Readers

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  • Molecular Genetics