Role of Tumor Collagenase Stimulating Factor in Breast Cancer Invasion and Metastasis

Abstract

Extracellular matrix metalloproteinase inhibitor (EMMPRIN), a plasma membrane glycoprotein identified originally in carcinoma cells, is responsible for inducing Ireritumoral fibroblasts to produce matrix metalloproteinases (MMPs), thereby enhancing cancer invasion and metastasis. Using in situ hybridization and immunohistochemistry, we have identified EMMPRIN in breast cancer tissue. We have characterized the human EMMPRIN gene and have noted a high degree of conservation with the mouse gene.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 1999
Accession Number
ADA382864

Entities

People

  • Stanley Zucker

Organizations

  • State University of New York

Tags

DTIC Thesaurus Topics

  • Breast Cancer
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Health Services
  • Medical Personnel

Fields of Study

  • Biology

Readers

  • Molecular Biology and Genetics