The Mechanism of E2F/P130 Mediated Repression and Its Potential Tumor Suppressor Function in Breast Cancer

Abstract

Transcription repression in quiescent cells is critical for the maintenance of cell growth control. Previous work has shown the importance of E2F-Rb and E2F-p13O complexes in promoting this transcriptional silencing, however, the mechanisms of action of these complexes has yet to be thoroughly elucidated. The purpose of the work supported by this grant, as stated in objective #1, is to identify the mechanisms of p13O mediated transcription repression. To this end we have established that histone deacetylase interacts with p13O as one mechanism of repression. Through a yeast two hybrid assay, we have also found a novel mechanism of p13O mediated repression that is independent of histone deacetylase action.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1999
Accession Number
ADA382889

Entities

People

  • Alison R. Meloni

Organizations

  • Duke University Hospital

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Breast Cancer
  • Carrier Proteins
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Enzyme Inhibitors
  • Genes
  • Genetic Structures
  • Genetics
  • Inhibition
  • Inhibitors
  • Intellectual Property
  • Laboratory Animals
  • Materials
  • Neoplasms
  • Proteins

Fields of Study

  • Biology

Readers

  • Molecular Genetics
  • Molecular and Cellular Biology
  • Molecular and genetic basis of cancer.