Tagging of Breast Tumors for Excision and Specimen Radiography and of Sentinel Nodes for Ultrasound-Guided Localization Using Novel Particulate Agents

Abstract

Our initial purpose is to mark the lesion for specimen radiography. This years experiments have been performed to determine the optimal amount and the persistence of the agent that can be injected without extravasation. Our grant seeks solutions to two related problems in breast tumor imaging: (1) Provide the ability to mark nonpalpable and non-radiopaque lesions to guide surgery and prove their resection on specimen radiography. (2) Mark and localize the sentinel node. The purpose of our first year's study was to prove our first hypothesis: When ImLN is injected in the lesion it will mark the region in vivo for days and it will mark the lesion on specimen radiography to confirm that the marked lesion is contained in the resected specimen.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Aug 01, 1999
Accession Number
ADA382950

Entities

People

  • Robert F. Mattrey

Organizations

  • University of California, San Diego

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Breast Cancer
  • Contrast
  • Emulsions
  • Excision
  • Guidance
  • Laboratory Animals
  • Lymph Nodes
  • Lymphatic System
  • Materials
  • Neoplasms
  • Radiography
  • Recombinant Dna
  • Surgery
  • Ultrasounds
  • X Rays
  • X-Ray Computed Tomography

Fields of Study

  • Medicine

Readers

  • Aerospace Test and Evaluation
  • Oncology (Cancer Research).
  • Oncology and Biomarker-Based Cancer Detection.