Estrogen Receptor Gene Polymorphisms and Breast Cancer Risk

Abstract

TO TEST THE HYPOTHESIS THAT INDIVIDUAL VARIATION IN THE SENSITIVITY TO ESTROGENS, WHETHER FROM ENDOGENOUS OR EXOGENOUS SOURCES, AFFECTS WOMAN 5 RISK OF BREAST CANCER. Scope: to test i(the variability in responses to estrogens in women may be determined by a functionally significant variation in the estrogen receptor alpha (ER) though which estrogens' exert biologic effects. The ER polymorphisms under study are: xba I, Pvu II and microsatelite polymorphisms. In an exploratory analysis we will study the interaction between the Xba I Pvu II and microsatellite ER polymorphisms and estrogen-related risk factors for breast cancer such as reproductive history and menopausal hormone use.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 1999
Accession Number
ADA383021

Entities

People

  • Habs-olov G. Adami
  • Landegran

Organizations

  • Uppsala University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Animals
  • Artificial Satellites
  • Biomedical Research
  • Blood
  • Blood Cells
  • Breast Cancer
  • Cancer
  • Cells
  • Hormones
  • Laboratory Animals
  • Leukocytes
  • Materials
  • Medical Personnel
  • Microsatellites
  • Neoplasms
  • Recombinant Dna
  • Risk Factors

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