Inhibition of Mammary Cancer by Citrus Limonoids

Abstract

Citrus limonoids are a class of chemically related compounds present in lemon, lime, orange and grapefruit. We have shown that nomilin and a limonoid glucoside mixture are potent inhibitors of proliferation of estrogen receptor%negative (ER-) and -positive (ER+) human breast cancer cells in culture. In the present experiments, we tested deacetylnomilin, deoxylimonin, ichangin, isoobacunoic acid, limonol, limonin carboxyrnethoxime, methyl deoxylimonate, methylnomilinate, methyl deacetylnomilinate, methyl isolimonate, nomilin glucoside, nomilinic acid glucoside, 7a-obacunol, obacunone and obacunone glucoside for their ability to inhibit the proliferation of MDA-MB-435 ER- and MCF-7 ER+ human breast cancer cells.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 1999
Accession Number
ADA383033

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People

  • Ted Vandenberg

Organizations

  • Western University

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  • Abstracts
  • Animals
  • Biomedical Research
  • Body Weight
  • Breast Cancer
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  • Chemistry
  • Estrogens
  • Glycosides
  • Hormones
  • Inhibition
  • Inhibitors
  • Laboratory Animals
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  • Neoplasms
  • Recombinant Dna
  • Tumor Cell Line

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