Signal Transduction and Gene Regulation During Hypoxic Stress: A Potential Role in Neurodegenerative Disease

Abstract

The primary objective of this research project is to determine the role of the mitogen-activated protein kinase (MAPK) pathways (specifically p38 kinase) in mediating the cellular response to hypoxia-stress. The overall scope of this project is to understand how neurons adapt to chronic hypoxia. The neural-like PC12 cell line is used as a model system to identify the molecular mechanisms that mediate tolerance to hypoxia. The inability to develop tolerance can lead to neurodegeneration and possibly cell death. Our work on this project resulted in the publication of 4 original papers, 1 review paper, and 1 book chapter.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2000
Accession Number
ADA383039

Entities

People

  • David E. Millhorn

Organizations

  • University of Cincinnati

Tags

DTIC Thesaurus Topics

  • Biological Sciences
  • Biotechnology
  • Carrier Proteins
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Health Services
  • Nervous System
  • Peptide Growth Factors
  • Peptides
  • Proteins
  • Stress (Physiology)
  • Transcription Factors
  • Tumor Cell Line

Fields of Study

  • Biology

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Neuroscience
  • Technical Research and Report Writing.