The p16 Pathway in Breast Cancer and Senescence Control

Abstract

Abnormalities affecting the INK4A locus are common in breast cancer. Disregulation of expression of the genes encoded by such locus (p16 and p14 to the ARF) affects most breast carcinomas. Overexpression of p16 associates with more aggressive breast cancer frequently. On the other hand, p16 inactivation is a key necessary event that HMEC use to achieve extended life in vitro and to overcome the MO senescence arrest. Future studies will address whether p14 to the ARF neutralization couples with p16 inactivation in HMBC are sufficient to achieve in vitro immortality.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1999
Accession Number
ADA383067

Entities

People

  • Claudio M. Aldaz

Organizations

  • The University of Texas MD Anderson Cancer Center

Tags

DTIC Thesaurus Topics

  • Antineoplastic Agents
  • Breast Cancer
  • Carcinoma
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Genetics
  • Medical Personnel
  • Neoplasms
  • Oncology

Readers

  • Molecular Biology and Genetics