Growth Inhibition of Breast Tumor Cells by Hypodense and Normodense Eosinophilic Cell Lines
Abstract
We have shown that cell lines developed from metrizamide density gradient fractions of peripheral blood hypodense (BJA.060.22) and hyperdense (BJA.060.24) eosinophils significantly inhibited MCF-7 colony formation in a dose-dependent fashion with as much as 82% inhibition ocurring at the E:T ratio of 1000: 1 (BJA.060.22 ) and 85% inhibition of MDA-MB-231 cells at the same E:T ratio. At 1000:1 E:T ratio, the hyperdense eosinophil cell line BJA.060.24 inhibited MCF-7 colony formation by half that of the hypodense line (44%) and MDA-MB-231 colony formation by 70%.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1999
- Accession Number
- ADA383068
Entities
People
- Paulette M. Furbert-harris
Organizations
- Howard University