How do Genetic Determinants of Bone Mass Relate to Breast Cancer Risk?

Abstract

The purpose of this study is to investigate the relationship between breast cancer risk, bone mass, and two polymorphic hormone receptor genes-- the estrogen receptor (ER) and vitamin D receptor (VDR) genes. We will also explore a possible functional mechanism to explain this association. We will recruit 200 new breast cancer cases and 200 controls, ages 40-85, with equal numbers of African-Americans and whites. Bone mineral density (BMD) measurements of the forearm will be obtained. We have enrolled 121 women (53 white and 20 African-American breast cancer, and 27 white and 21 African- American controls), with an age range of 40-81. We have increased monthly recruitment from 7 per month in the first 3 months to an average of 19 subjects per month in the past 3 months, which should allow accrual of 400 subjects as planned.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1999
Accession Number
ADA383075

Entities

People

  • Dorothy A. Nelson

Organizations

  • Wayne State University

Tags

DTIC Thesaurus Topics

  • African Americans
  • Age Distribution
  • Biomedical Research
  • Breast Cancer
  • Databases
  • Ethnic Groups
  • Frequency
  • Genes
  • Genotypes
  • Laboratory Animals
  • Materials
  • Measurement
  • Musculoskeletal Physiology
  • Neoplasms
  • Pilot Studies
  • Recombinant Dna
  • Vitamin D

Readers

  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.

Technology Areas

  • Biotechnology