Modulation of Molecular Markers by CLA

Abstract

Conjugated linoleic acid (CLA) is a potent inhibitor of experimentally-induced mammary carcinogenesis. Both chemically pure as well as naturally occurring forms of CLA exert this cancer preventive activity. While CLA can reduce levels of lipid peroxidation in the mammary gland, this apparent antioxidant effect may be secondary to a primary effect on CLA on suppressing the metabolism of linoleic acid. Suppression of linoleic acid metabolism may also account for the effects of CLA in decreasing mammary gland density and in inhibiting rates of cell proliferation in structural elements of the mammary gland that are targets for neoplastic transformation. Collectively, these data justify additional pre-clinical and clinical studies to evaluate the safety and efficacy of CLA for the prevention of human breast cancer.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1999
Accession Number
ADA383220

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  • Henry Thompson

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  • Antineoplastic Agents
  • Breast Cancer
  • Cell Physiological Processes
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  • Atmospheric Science/Meteorology
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  • Molecular and genetic basis of cancer.