The Role of Parathyroid Hormone-Related Protein in Breast Cancer Mediated Osteolysis

Abstract

Breast cancer affects the skeleton through humoral and local osteolytic mechanisms to cause the devastating complications of hypercalcemia, pain, fracture and nerve compression syndromes. PTHrP mediates hypercalcemia through its systemic effects to increase osteoclastic bone resorption as well as renal tubular calcium reabsorption in at least 50% of hypercalcemic breast cancer patients even in the presence of bone metastases. Due to this potent bone resorbing capacity, PTHrP expression in the primary tumor may aid in establishment of the bone metastases that are characteristic of patients with breast cancer. This final report summarizes the findings of the funding period. 50% of breast cancer cell lines tested secrete low, but significant amounts of PTHrP.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1999
Accession Number
ADA383256

Entities

People

  • Theresa Gruise

Organizations

  • University of Texas at San Antonio

Tags

DTIC Thesaurus Topics

  • Bone And Bones
  • Bone Diseases
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Health Services
  • Medical Personnel
  • Peptide Growth Factors

Fields of Study

  • Medicine

Readers

  • Oncology (Cancer Research).