Gene Transfer Studies of the Pathogenesis and Treatment of Parkinson's Disease

Abstract

The overall aim of this research is to use a recombinant multiply deleted genomic herpes simplex virus type-i (HSV-l) based gene transfer vector to test the hypotheses that gene transfer of the glial derived neurotrophic factor (GDNF) or bcl-2 can slow or prevent the apoptotic death of nigral neurons in animal models of PD, and that expression of tyrosine hydroxylase (TH) can improve symptoms.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2000
Accession Number
ADA383307

Entities

People

  • Joseph C. Glorioso

Organizations

  • University of Pittsburgh

Tags

DTIC Thesaurus Topics

  • Apoptosis
  • Brain
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Coinfection
  • Department Of Veterans Affairs
  • Diseases And Disorders
  • Gene Therapy
  • Genetics
  • Intracellular Membranes
  • Nervous System
  • Nervous System Diseases
  • Neurons
  • Parkinson'S Disease
  • Proteins
  • Surgery

Fields of Study

  • Biology

Readers

  • Molecular Genetics
  • Neurodegenerative Parkinson's Disease and Rickettsial Disease handbook, including the data level of dopamine, BC, neurons, and PD.