Characterization of BC1-2, BC1-XL, and Bax Pore Formation and Their Role in Apoptosis Regulation

Abstract

The Bcl-2 protein family plays an important role in governing a cell's decision to live or die. Dysregulation of these proteins is observed in many breast cancer cases and thus it is important to understand their mechanism in order to develop new treatments. The Bcl-X(L) protein structure showed a strong similarity to pore-forming bacterial toxins, suggesting that Bcl-2 protein - family protein may regulate apoptosis by pore formation or membrane insertion. The results obtained this year include characterization of membrane binding of these proteins to lipid vesicles.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1999
Accession Number
ADA383308

Entities

People

  • Sharon L. Schendel

Organizations

  • Sanford Burnham Prebys Medical Discovery Institute

Tags

DTIC Thesaurus Topics

  • Amines
  • Amino Acids
  • Biomedical And Dental Materials
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Fungi
  • Intracellular Membranes
  • Membrane Lipids
  • Membrane Potentials
  • Programmed Cell Death
  • Surface Plasmon Resonance
  • Synthetic Membranes
  • Three Dimensional

Fields of Study

  • Biology

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Molecular Genetics