Metallo-Network Polymers: Biomimetic Metal Binding/Recognition Sites

Abstract

New composite materials have been designed and fabricated with funds provided by ONR/DESPCoR grant N00014-96-1-1216. Copolymers have been developed from molecular precursors, which dispersed metal complexes throughout highly crosslinked, porous organic hosts. These materials have been applied to problems in gas storage/release and transport, and sensor technology. They are durable, function in water and organic solvents, and maintain their binding site structures. Materials that reversibly bind O2 and NO have been designed and synthesized. Rapid and reversibly dioxygen binding is observed with dioxygen binding capacities of approximately 160 micro mol O2/g polymer. Biomedical applications include artery (smooth muscle) relaxation under biologically relevant conditions, which is induced by the release of NO from a NO-containing polymer. This NO-releasing material also inhibits platelet formation in an in vitro assay.

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Document Details

Document Type
Technical Report
Publication Date
Oct 10, 2000
Accession Number
ADA383458

Entities

People

  • A. S. Borovik

Organizations

  • University of Kansas

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Chemical Compounds
  • Chemical Reactions
  • Chemistry
  • Composite Materials
  • Coordination Complexes
  • Copolymers
  • Films
  • Inorganic Chemistry
  • Materials
  • Metalloproteins
  • Molecules
  • Muscles
  • Polymers
  • Porous Materials
  • Recognition
  • Smooth Muscle

Fields of Study

  • Chemistry
  • Materials science

Readers

  • Nanocomposite Materials Science
  • Organic Chemistry
  • Trauma Surgery or Emergency Medicine.

Technology Areas

  • Biotechnology
  • Microelectronics