Growth Receptors and Integrins in Breast Cancer

Abstract

The central hypothesis of this IDEA Award is that epidermal growth factor (EGF) receptors in breast cancer transduce intracellular signals that lead to activation of the lipid kinase phosphoinositide 3-OH kinase (PI 3-K) and rapid increases in the functional activity of integrin adhesion receptors, thereby regulating breast cancer cell motility and invasiveness. During the course of this IDEA Award, we have established the validity of this hypothesis. EGF and betacellulin, ligands that activate the EGFR, and heregulin- (beta, a ligand that activates erbB3 and erbB4, induce dose and time-dependent adhesion of MDA-MB-435 cells to type IV collagen via (beta 1 integrins. These same growth factors also upregulate beta 1 integrin mediated adhesion on collagen and laminin. Inhibition of PI 3-K activity blocks both adhesion and migration induced by these growth factors.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 1999
Accession Number
ADA383604

Entities

People

  • Yoji Shimizu

Organizations

  • University of Minnesota

Tags

DTIC Thesaurus Topics

  • Adhesion
  • Breast Cancer
  • Cell Line
  • Cell Movement
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Culture Media
  • Growth Factors
  • Lymphocytes
  • Medical Personnel
  • Molecules
  • Neoplasms
  • Peptide Growth Factors
  • Peptides
  • Proteins

Fields of Study

  • Biology

Readers

  • Breast cancer cell signaling and growth regulation.