Characterization of CTL Recognized Epitopes on Human Breast Tumors
Abstract
Studies during the last granting period were focused on the activating ability of tumor Ag identified from HER-2 and FBP for T cells from breast cancer patients. Ongoing studies focuses on improvement of Ag presentation and enhanced activation of CTL functions concludes that: (1) IL-l2 is required for early and rapid IFN- induction in response to tumor Ag. This was established using both randomly selected breast cancer patients, and patients vaccinated with HER-2 tumor Ag, E75 using GM-CSF as adjuvant; (2) Tumor Ag such as E75 induce the angiostatic/anti-angiogenic chemokine IP-lO from responder lymphocytes (3). Enhanced Ag presentation and immunogenicity can be achieved by inducing Ser/Thr phosphorylation of HER-2.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1999
- Accession Number
- ADA383880
Entities
People
- Constantin G. Ioannides
Organizations
- University of Texas at Austin