Immunological Prevention of Spontaneous Mammary Carcinoma in Transgenic Mice
Abstract
Our purpose is to explore the possibility of employing immunological intervention to hamper the carcinogenic process and the growth of spontaneous mammary carcinomas in mice. The final aim is to get enough information to decide whether a similar approach may be applied in humans at risk. The mammary glands of female Balblc and FVB mice transgenic for the activated or amplified rat Her2/neu oncogene progress to carcinomas. We were able to significantly delay this carcinogenic process using repeated administrations of interleukin 12, which elicited the immune response of the host and inhibited tumor growth through the induction of antiangiogenic chemokines. An almost complete inhibition of tumorigenesis was obtained using a combination of IL-12 and of a vaccine containing allogeneic neu-postive tumor cells. The results support the idea that antigen specific and nonspecific signals are required to elicit an immune response that can protect the host from an ongoing carcinogenic process.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2000
- Accession Number
- ADA384037
Entities
People
- Guido Forni
Organizations
- University of Turin