Quantitative Breast Lesion Imaging and Characterization Using a Combined X-Ray CT-Gamma Camera Methodology
Abstract
The purpose of this research is to develop tools and techniques for the measurement of radionuclide uptake in breast lesions using a combined x-ray CT-scintillation camera imaging system. The developed techniques are also potentially useful for other types of cancers, as well as for other diseases. Major projects in this initial funding year include: (1) assessment of x-ray radiation dose for CT-mammography, (2) Monte Carlo modeling of breast imaging for the combined system, and (3) initial experimental radionuclide phantom studies using the imaging system. Typical mean glandular dose for x-ray CT is 450 mRem for a 140 kVp tube potential and a tube current x time technique of 80 mAs. Dose depends on tube potential, tube current, and scan time, but not slice thickness. Monte Carlo modeling of the imaging process suggests up to a 10% measurement bias due to the effects of scattered photons. While smaller than effects due to limited spatial resolution, this bias becomes more significant as resolution corrections are made using CT-defined size and shape information. Evaluation of experimental data awaits further experimental acquisitions in the coming months. However, progress has been made in completing the goals specified in the Statement of Work for Year 1.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1999
- Accession Number
- ADA384050
Entities
People
- Hamilton R. Tang
Organizations
- University of California, San Francisco