Vascular Functional Imaging and Physiological Environment of Hyperplasia, Non-Metastatic and Metastatic Breast Cancer
Abstract
Our technological developments of obtaining multi-slice data together with our novel software program for image analysis have allowed us to obtain comprehensive information of tumor vascular volume and permeability as well as histological morphology and examine the relationship between vascular volume and permeability. In year 3 we have used the significant technical developments implemented in year 2 to determine the vascular characteristics of human breast cancer cells preselected for differences in invasive and metastatic behavior. The results obtained demonstrate that the more metastatic cell lines are characterized by higher vascular volume and vascular permeability in vivo. The analysis was performed for regions of high vascular volume and permeability. We also confirmed our earlier observations that regions of high vascular volume and regions of high vascular permeability do not coincide spatially. The results indicate a potential use of MRI for evaluating ' metastatic risk' noninvasively.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1999
- Accession Number
- ADA384089
Entities
People
- Zaver Bhujwalla
Organizations
- Johns Hopkins University